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Stollingsteenmiddel

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'n Stollingsteenmiddel, algemeen bekend as 'n bloedverdunner, is 'n chemiese stof wat die stolling van bloed voorkom of verminder en sodoende die stollingstyd verleng.[1] Sommige kom natuurlik voor in bloedsuiende diere, soos bloedsuiers en muskiete, wat help om die bytplek lank genoeg ongestol te hou sodat die dier bloed kan kry.[2][3]

As 'n klas farmaseutiese middels word stollingsteenmiddels in die behandeling van trombotiese afwykings gebruik.[4] Orale stollingsteenmiddels word deur baie mense in die vorm van tablette geneem, en verskeie binneaarse middels word in hospitale gebruik.[5][6]

Een van die eerste stollingsteenmiddels, warfarin, is aanvanklik as 'n knaagdierdoder goedgekeur.[7] Stollingsteenmiddels is nou verwant aan antiplaatjiemiddels en trombolitiese middels omdat hulle die verskillende roetes van bloedstolling beïnvloed.[8]

Algemene stollingsteenmiddels sluit warfarin en heparien in.[9]

Verwysings

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  1. ↑ "Overview: Anticoagulant medicines". Health A to Z. NHS. 26 Julie 2021. Besoek op 2 Junie 2023.
  2. ↑ Azzopardi EA, Whitaker IS, Rozen WM, Naderi N, Kon M (Oktober 2011). "Chemical and mechanical alternatives to leech therapy: a systematic review and critical appraisal". Journal of Reconstructive Microsurgery. 27 (8). Thieme Medical Publishers: 481–86. doi:10.1055/s-0031-1284233. eISSN 0743-684X. PMID 21780018. S2CID 260192613.
  3. ↑ Ha YR, Oh SR, Seo ES, Kim BH, Lee DK, Lee SJ (April 2014). "Detection of heparin in the salivary gland and midgut of Aedes togoi". The Korean Journal of Parasitology. 52 (2). The Korean Society for Parasitology and Tropical Medicine: 183–88. doi:10.3347/kjp.2014.52.2.183. eISSN 2982-6799. PMC 4028456. PMID 24850962.
  4. ↑ Yoo HH, Nunes-Nogueira VS, Boas, PJ (7 Februarie 2020). "Anticoagulant treatment for subsegmental pulmonary embolism". The Cochrane Database of Systematic Reviews. 2020 (2) CD010222. doi:10.1002/14651858.CD010222.pub4. ISSN 1469-493X. PMC 7004894. PMID 32030721.
  5. ↑ Cohen AT, Hamilton M, Mitchell SA, Phatak H, Liu X, Bird A, Tushabe D, Batson S (30 Desember 2015). ten Cate H (red.). "Comparison of the Novel Oral Anticoagulants Apixaban, Dabigatran, Edoxaban, and Rivaroxaban in the Initial and Long-Term Treatment and Prevention of Venous Thromboembolism: Systematic Review and Network Meta-Analysis". [LOS One. 10 (12) e0144856. Bibcode:2015PLoSO..1044856C. doi:10.1371/journal.pone.0144856. PMC 4696796. PMID 26716830.
  6. ↑ Almutairi AR, Zhou L, Gellad WF, Lee JK, Slack MK, Martin JR, Lo-Ciganic WH (Julie 2017). "Effectiveness and Safety of Non-vitamin K Antagonist Oral Anticoagulants for Atrial Fibrillation and Venous Thromboembolism: A Systematic Review and Meta-analyses". Clinical Therapeutics. 39 (7): 1456–78.e36. doi:10.1016/j.clinthera.2017.05.358. PMID 28668628.
  7. ↑ Pirmohamed M (November 2006). "Warfarin: almost 60 years old and still causing problems". British Journal of Clinical Pharmacology. 62 (5): 509–11. doi:10.1111/j.1365-2125.2006.02806.x. PMC 1885167. PMID 17061959.
  8. ↑ Patel, S.; Singh, R.; Preuss, C. V.; Patel, N. (2020). "Warfarin". StatPearls. StatPearls Publishing. PMID 29261922. Besoek op 23 Januarie 2020.
  9. ↑ Winslow, Ron; Johnson, Avery (10 Desember 2007). "Race Is on for the Next Blood Thinner". The Wall Street Journal. p. A12. Besoek op 6 Januarie 2008.

Skakels

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